تداخل‌های دارویی
Cenobamate + Ethinyl estradiol-levonorgestrel
شدت: شدید
Cenobamate and Ethinyl estradiol-levonorgestrel: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Cenobamate induces CYP3A4 and can lower exposure to ethinyl estradiol and levonorgestrel. This may reduce contraceptive efficacy and raise the risk of unintended pregnancy and breakthrough bleeding.
معنای این تداخل به زبان ساده
Cenobamate and Ethinyl estradiol-levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cenobamate belongs to Central Nervous System; Ethinyl estradiol-levonorgestrel belongs to Endocrine.
چرا رخ می‌دهد
Cenobamate induces CYP3A4 (and other enzymes), increasing metabolism of both contraceptive hormones.
اقدام لازم
Advise an additional or alternative non-hormonal contraceptive method during and for some time after cenobamate therapy. Consider a higher-dose or alternative contraceptive approach, such as an intrauterine device.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Cenobamate و Ethinyl estradiol-levonorgestrel، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant منع مصرف
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir منع مصرف
- Ethinyl estradiol-levonorgestrel + Tranexamic acid منع مصرف
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel شدید
- Amobarbital + Ethinyl estradiol-levonorgestrel شدید
- Anastrozole + Ethinyl estradiol-levonorgestrel شدید
تداخلات دیگر Cenobamate
پرسش‌های متداول
Can I take Cenobamate with Ethinyl estradiol-levonorgestrel?
MediHelp rates the interaction as major. Cenobamate and Ethinyl estradiol-levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cenobamate induces CYP3A4 and can lower exposure to ethinyl estradiol and levonorgestrel. This may reduce contraceptive efficacy and raise the risk of unintended pregnancy and breakthrough bleeding.
How serious is the interaction between Cenobamate and Ethinyl estradiol-levonorgestrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional or alternative non-hormonal contraceptive method during and for some time after cenobamate therapy. Consider a higher-dose or alternative contraceptive approach, such as an intrauterine device.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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