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تداخل‌های دارویی

Certolizumab pegol + Vedolizumab

شدت: شدید

Certolizumab pegol and Vedolizumab: major interaction.

آخرین به‌روزرسانی

ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.

محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Vedolizumab labeling advises against concomitant TNF blockers because of potential for more infections. Combining them has not shown clear benefit.

معنای این تداخل به زبان ساده

Certolizumab pegol and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Certolizumab pegol belongs to Musculoskeletal; Vedolizumab belongs to Gastrointestinal Tract.

سطح شواهد: Moderate

چرا رخ می‌دهد

Additive immunosuppression from systemic TNF-alpha blockade and gut-selective alpha4beta7 integrin inhibition.

اقدام لازم

Avoid concomitant use; transition between agents rather than overlap. Monitor for infection if overlap occurs.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Certolizumab pegol و Vedolizumab، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۷ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Certolizumab pegol with Vedolizumab?

MediHelp rates the interaction as major. Certolizumab pegol and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vedolizumab labeling advises against concomitant TNF blockers because of potential for more infections. Combining them has not shown clear benefit.

How serious is the interaction between Certolizumab pegol and Vedolizumab?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use; transition between agents rather than overlap. Monitor for infection if overlap occurs.

What other medicines interact with Certolizumab pegol?

MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.

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