Drug interactions
Certolizumab pegol + Vedolizumab
Severity: Major
Certolizumab pegol and Vedolizumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vedolizumab labeling advises against concomitant TNF blockers because of potential for more infections. Combining them has not shown clear benefit.
What this interaction means in plain words
Certolizumab pegol and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Certolizumab pegol belongs to Musculoskeletal; Vedolizumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression from systemic TNF-alpha blockade and gut-selective alpha4beta7 integrin inhibition.
What to do
Avoid concomitant use; transition between agents rather than overlap. Monitor for infection if overlap occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
- Upadacitinib + Vedolizumab Major
Frequently asked questions
Can I take Certolizumab pegol with Vedolizumab?
MediHelp rates the interaction as major. Certolizumab pegol and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vedolizumab labeling advises against concomitant TNF blockers because of potential for more infections. Combining them has not shown clear benefit.
How serious is the interaction between Certolizumab pegol and Vedolizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use; transition between agents rather than overlap. Monitor for infection if overlap occurs.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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