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تداخل‌های دارویی

Chlorpromazine + Osimertinib

شدت: شدید

Chlorpromazine and Osimertinib: major interaction.

آخرین به‌روزرسانی

ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.

محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Both agents can prolong the QTc interval, and combined use may increase the risk of ventricular arrhythmias including torsades de pointes. The risk is higher with electrolyte disturbances or underlying cardiac disease.

معنای این تداخل به زبان ساده

Chlorpromazine and Osimertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Chlorpromazine belongs to Central Nervous System; Osimertinib belongs to Oncology.

سطح شواهد: Moderate

چرا رخ می‌دهد

Additive QT prolongation through cardiac repolarization effects.

اقدام لازم

Perform ECG and electrolyte monitoring at baseline and periodically, and correct hypokalemia and hypomagnesemia. Avoid the combination or consider alternatives in patients with congenital long QT or a markedly prolonged QTc.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Chlorpromazine و Osimertinib، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Chlorpromazine with Osimertinib?

MediHelp rates the interaction as major. Chlorpromazine and Osimertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QTc interval, and combined use may increase the risk of ventricular arrhythmias including torsades de pointes. The risk is higher with electrolyte disturbances or underlying cardiac disease.

How serious is the interaction between Chlorpromazine and Osimertinib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform ECG and electrolyte monitoring at baseline and periodically, and correct hypokalemia and hypomagnesemia. Avoid the combination or consider alternatives in patients with congenital long QT or a markedly prolonged QTc.

What other medicines interact with Chlorpromazine?

MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.

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