تداخل‌های دارویی
Cilastatin-imipenem + Divalproex
شدت: شدید
Cilastatin-imipenem and Divalproex: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Carbapenems, including imipenem, cause a rapid and marked fall in serum valproate concentrations. This can lead to loss of seizure control, and the effect may persist for days after stopping the carbapenem. Increasing the valproate dose does not reliably overcome it.
معنای این تداخل به زبان ساده
Cilastatin-imipenem and Divalproex can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
چرا رخ می‌دهد
Carbapenems inhibit acylpeptide hydrolase, reducing hydrolysis of valproate glucuronide back to valproate, and may also decrease valproate absorption and distribution into tissues.
اقدام لازم
Avoid the combination and use a non-carbapenem antibiotic. If a carbapenem is essential, add alternative anticonvulsant coverage and monitor valproate levels and seizure activity.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Cilastatin-imipenem و Divalproex، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Cilastatin-imipenem
پرسش‌های متداول
Can I take Cilastatin-imipenem with Divalproex?
MediHelp rates the interaction as major. Cilastatin-imipenem and Divalproex can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbapenems, including imipenem, cause a rapid and marked fall in serum valproate concentrations. This can lead to loss of seizure control, and the effect may persist for days after stopping the carbapenem. Increasing the valproate dose does not reliably overcome it.
How serious is the interaction between Cilastatin-imipenem and Divalproex?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-carbapenem antibiotic. If a carbapenem is essential, add alternative anticonvulsant coverage and monitor valproate levels and seizure activity.
What other medicines interact with Cilastatin-imipenem?
MediHelp also lists interactions of Cilastatin-imipenem with, for example, Ganciclovir, Valproic acid, Bcg intravesical live. The full list is on the Cilastatin-imipenem page.
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