تداخل‌های دارویی
Cilastatin-imipenem + Ganciclovir
شدت: شدید
Cilastatin-imipenem and Ganciclovir: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Generalized seizures have been reported in patients receiving ganciclovir together with imipenem-cilastatin. Both drugs can lower seizure threshold, particularly in renal impairment.
معنای این تداخل به زبان ساده
Cilastatin-imipenem and Ganciclovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cilastatin-imipenem belongs to Anti Bacterial; Ganciclovir belongs to Anti Virals.
چرا رخ می‌دهد
The mechanism is not well established and is probably additive lowering of seizure threshold.
اقدام لازم
Avoid the combination unless the benefit clearly outweighs the risk, and consider a non-carbapenem antibiotic. If used, adjust doses for renal function and monitor for neurological toxicity.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Cilastatin-imipenem و Ganciclovir، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Cilastatin-imipenem
تداخلات دیگر Ganciclovir
پرسش‌های متداول
Can I take Cilastatin-imipenem with Ganciclovir?
MediHelp rates the interaction as major. Cilastatin-imipenem and Ganciclovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Generalized seizures have been reported in patients receiving ganciclovir together with imipenem-cilastatin. Both drugs can lower seizure threshold, particularly in renal impairment.
How serious is the interaction between Cilastatin-imipenem and Ganciclovir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination unless the benefit clearly outweighs the risk, and consider a non-carbapenem antibiotic. If used, adjust doses for renal function and monitor for neurological toxicity.
What other medicines interact with Cilastatin-imipenem?
MediHelp also lists interactions of Cilastatin-imipenem with, for example, Divalproex, Valproic acid, Bcg intravesical live. The full list is on the Cilastatin-imipenem page.
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