تداخل‌های دارویی
Cisatracurium + Colistin
شدت: شدید
Cisatracurium and Colistin: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Colistin (polymyxin E) can cause neuromuscular blockade by itself and may potentiate non-depolarizing relaxants such as cisatracurium. Prolonged paralysis and respiratory failure have been described with polymyxins.
معنای این تداخل به زبان ساده
Cisatracurium and Colistin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisatracurium belongs to Musculoskeletal; Colistin belongs to Anti Bacterial.
چرا رخ می‌دهد
Colistin reduces presynaptic acetylcholine release and stabilizes the postsynaptic membrane, adding to nicotinic receptor blockade by cisatracurium.
اقدام لازم
Avoid co-administration where possible; if unavoidable, reduce cisatracurium dosing and monitor with train-of-four. Have ventilatory support available, and note that calcium or neostigmine may only partly reverse the effect.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Cisatracurium و Colistin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Cisatracurium
تداخلات دیگر Colistin
پرسش‌های متداول
Can I take Cisatracurium with Colistin?
MediHelp rates the interaction as major. Cisatracurium and Colistin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Colistin (polymyxin E) can cause neuromuscular blockade by itself and may potentiate non-depolarizing relaxants such as cisatracurium. Prolonged paralysis and respiratory failure have been described with polymyxins.
How serious is the interaction between Cisatracurium and Colistin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid co-administration where possible; if unavoidable, reduce cisatracurium dosing and monitor with train-of-four. Have ventilatory support available, and note that calcium or neostigmine may only partly reverse the effect.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
