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تداخل‌های دارویی

Clarithromycin + Eletriptan

شدت: منع مصرف

Clarithromycin and Eletriptan: contraindicated interaction.

آخرین به‌روزرسانی

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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Clarithromycin is a strong CYP3A4 inhibitor, and eletriptan is cleared largely by CYP3A4. Raised eletriptan exposure can lead to excessive eletriptan effect, including vasoconstriction and coronary spasm.

معنای این تداخل به زبان ساده

Clarithromycin and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Clarithromycin belongs to Anti Bacterial; Eletriptan belongs to Central Nervous System.

سطح شواهد: High

چرا رخ می‌دهد

CYP3A4 inhibition by clarithromycin reduces first-pass and systemic clearance of eletriptan

اقدام لازم

Do not combine; choose an alternative to clarithromycin.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Clarithromycin و Eletriptan، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Clarithromycin with Eletriptan?

MediHelp rates the interaction as contraindicated. Clarithromycin and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin is a strong CYP3A4 inhibitor, and eletriptan is cleared largely by CYP3A4. Raised eletriptan exposure can lead to excessive eletriptan effect, including vasoconstriction and coronary spasm.

How serious is the interaction between Clarithromycin and Eletriptan?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose an alternative to clarithromycin.

What other medicines interact with Clarithromycin?

MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.

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