تداخل‌های دارویی
Cobicistat + Eletriptan
شدت: منع مصرف
Cobicistat and Eletriptan: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Cobicistat is a strong CYP3A4 inhibitor and markedly raises eletriptan exposure, which increases the risk of triptan toxicity including vasoconstriction and hypertension. Eletriptan labeling contraindicates use with strong CYP3A4 inhibitors.
معنای این تداخل به زبان ساده
Cobicistat and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cobicistat belongs to Miscellaneous; Eletriptan belongs to Central Nervous System.
چرا رخ می‌دهد
Inhibition of CYP3A4-mediated metabolism of eletriptan, increasing its plasma concentrations.
اقدام لازم
Do not use eletriptan during or within about 72 hours of cobicistat. Use a triptan not dependent on CYP3A4, such as rizatriptan or sumatriptan, if one is needed.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Cobicistat و Eletriptan، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Eletriptan
- Almotriptan + Eletriptan منع مصرف
- Atazanavir + Eletriptan منع مصرف
- Ceritinib + Eletriptan منع مصرف
- Clarithromycin + Eletriptan منع مصرف
- Conivaptan + Eletriptan منع مصرف
- Darunavir + Eletriptan منع مصرف
تداخلات دیگر Cobicistat
- Alfuzosin + Cobicistat منع مصرف
- Apalutamide + Cobicistat منع مصرف
- Cobicistat + Colchicine منع مصرف
- Cobicistat + Dronedarone منع مصرف
- Cobicistat + Eplerenone منع مصرف
- Cobicistat + Ergotamine منع مصرف
پرسش‌های متداول
Can I take Cobicistat with Eletriptan?
MediHelp rates the interaction as contraindicated. Cobicistat and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat is a strong CYP3A4 inhibitor and markedly raises eletriptan exposure, which increases the risk of triptan toxicity including vasoconstriction and hypertension. Eletriptan labeling contraindicates use with strong CYP3A4 inhibitors.
How serious is the interaction between Cobicistat and Eletriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use eletriptan during or within about 72 hours of cobicistat. Use a triptan not dependent on CYP3A4, such as rizatriptan or sumatriptan, if one is needed.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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