تداخل‌های دارویی
Clarithromycin + Ergotamine
شدت: منع مصرف
Clarithromycin and Ergotamine: contraindicated interaction.
آخرین به‌روزرسانی منابع: US FDA label
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Clarithromycin increases ergotamine concentrations and has been associated with acute ergot toxicity, including severe vasospasm and ischemia of the extremities, central nervous system and heart. Serious ischemic complications have been reported, sometimes after only a few doses. Concomitant use is contraindicated in product labeling.
معنای این تداخل به زبان ساده
Clarithromycin and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Ergotamine belongs to Central Nervous System.
چرا رخ می‌دهد
Clarithromycin strongly inhibits CYP3A4, reducing the metabolism of ergotamine and causing excessive exposure and vasoconstriction.
اقدام لازم
Do not combine; choose a non-interacting antibiotic such as azithromycin (weaker effect) or another class suited to the infection if an ergot is needed. Alternatively withhold ergotamine and treat migraine with a non-ergot agent while clarithromycin is given.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Clarithromycin و Ergotamine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
منابع
تداخلات دیگر Ergotamine
- Almotriptan + Ergotamine منع مصرف
- Atazanavir + Ergotamine منع مصرف
- Cobicistat + Ergotamine منع مصرف
- Darunavir + Ergotamine منع مصرف
- Dihydroergotamine intranasal + Ergotamine منع مصرف
- Dihydroergotamine + Ergotamine منع مصرف
تداخلات دیگر Clarithromycin
- Astemizole + Clarithromycin منع مصرف
- Avanafil + Clarithromycin منع مصرف
- Cisapride + Clarithromycin منع مصرف
- Clarithromycin + Colchicine منع مصرف
- Clarithromycin + Conivaptan منع مصرف
- Clarithromycin + Dihydroergotamine منع مصرف
پرسش‌های متداول
Can I take Clarithromycin with Ergotamine?
MediHelp rates the interaction as contraindicated. Clarithromycin and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin increases ergotamine concentrations and has been associated with acute ergot toxicity, including severe vasospasm and ischemia of the extremities, central nervous system and heart. Serious ischemic complications have been reported, sometimes after only a few doses. Concomitant use is contraindicated in product labeling.
How serious is the interaction between Clarithromycin and Ergotamine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose a non-interacting antibiotic such as azithromycin (weaker effect) or another class suited to the infection if an ergot is needed. Alternatively withhold ergotamine and treat migraine with a non-ergot agent while clarithromycin is given.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Cobicistat. The full list is on the Ergotamine page.
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