تداخل‌های دارویی
Cyclophosphamide + Pentostatin
شدت: شدید
Cyclophosphamide and Pentostatin: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Pentostatin combined with high-dose cyclophosphamide in transplant conditioning regimens has been associated with fatal pulmonary edema and hypotension. The combination also increases overall toxicity of both agents.
معنای این تداخل به زبان ساده
Cyclophosphamide and Pentostatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclophosphamide belongs to Oncology; Pentostatin belongs to Oncology.
چرا رخ می‌دهد
Additive cardiopulmonary and cytotoxic toxicity; the precise mechanism is not fully established.
اقدام لازم
Avoid pentostatin with high-dose cyclophosphamide in ablative transplant regimens. If standard-dose combinations are used, monitor fluid status, blood pressure and respiratory function closely.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Cyclophosphamide و Pentostatin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Pentostatin
- Carmustine + Pentostatin منع مصرف
- Etoposide + Pentostatin منع مصرف
- Fludarabine + Pentostatin منع مصرف
- Deferiprone + Pentostatin شدید
- Fingolimod + Pentostatin شدید
- Nelarabine + Pentostatin شدید
تداخلات دیگر Cyclophosphamide
پرسش‌های متداول
Can I take Cyclophosphamide with Pentostatin?
MediHelp rates the interaction as major. Cyclophosphamide and Pentostatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pentostatin combined with high-dose cyclophosphamide in transplant conditioning regimens has been associated with fatal pulmonary edema and hypotension. The combination also increases overall toxicity of both agents.
How serious is the interaction between Cyclophosphamide and Pentostatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid pentostatin with high-dose cyclophosphamide in ablative transplant regimens. If standard-dose combinations are used, monitor fluid status, blood pressure and respiratory function closely.
What other medicines interact with Pentostatin?
MediHelp also lists interactions of Pentostatin with, for example, Carmustine, Etoposide, Fludarabine. The full list is on the Pentostatin page.
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