تداخل‌های دارویی
Cyclosporin + Griseofulvin
شدت: شدید
Cyclosporin and Griseofulvin: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Griseofulvin can lower cyclosporine blood concentrations, and this has been associated with loss of immunosuppression and graft rejection in case reports. The effect may develop over days to weeks and can persist after griseofulvin is stopped.
معنای این تداخل به زبان ساده
Cyclosporin and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Griseofulvin belongs to Anti Fungals.
چرا رخ می‌دهد
Griseofulvin induces hepatic and intestinal CYP3A4, accelerating cyclosporine metabolism.
اقدام لازم
Avoid the combination in transplant patients where possible and consider an alternative antifungal such as terbinafine. If it is unavoidable, monitor cyclosporine trough levels frequently and increase the dose as needed.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Cyclosporin و Griseofulvin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۷ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin منع مصرف
- Aliskiren + Cyclosporin منع مصرف
- Bcg vaccine live + Cyclosporin منع مصرف
- Bosentan + Cyclosporin منع مصرف
- Cidofovir + Cyclosporin منع مصرف
- Cyclosporin + Dengue vaccine منع مصرف
تداخلات دیگر Griseofulvin
پرسش‌های متداول
Can I take Cyclosporin with Griseofulvin?
MediHelp rates the interaction as major. Cyclosporin and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Griseofulvin can lower cyclosporine blood concentrations, and this has been associated with loss of immunosuppression and graft rejection in case reports. The effect may develop over days to weeks and can persist after griseofulvin is stopped.
How serious is the interaction between Cyclosporin and Griseofulvin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in transplant patients where possible and consider an alternative antifungal such as terbinafine. If it is unavoidable, monitor cyclosporine trough levels frequently and increase the dose as needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
