تداخل‌های دارویی
Ethinyl estradiol-drospirenone + Griseofulvin
شدت: شدید
Ethinyl estradiol-drospirenone and Griseofulvin: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Griseofulvin has been associated with breakthrough bleeding, menstrual irregularities and reduced reliability of combined oral contraceptives. Contraceptive failure and unintended pregnancy are possible, which is especially important because griseofulvin is potentially teratogenic.
معنای این تداخل به زبان ساده
Ethinyl estradiol-drospirenone and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ethinyl estradiol-drospirenone belongs to Endocrine; Griseofulvin belongs to Anti Fungals.
چرا رخ می‌دهد
Griseofulvin is thought to induce hepatic enzymes (CYP3A4) and increase metabolism of ethinyl estradiol and the progestin, lowering their exposure.
اقدام لازم
Add a reliable non-hormonal barrier method throughout griseofulvin therapy and for at least one month after stopping. Consider an alternative antifungal where possible.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Ethinyl estradiol-drospirenone و Griseofulvin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۷ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant منع مصرف
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir منع مصرف
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir منع مصرف
- Ethinyl estradiol-drospirenone + Tranexamic acid منع مصرف
- Aminocaproic acid + Ethinyl estradiol-drospirenone شدید
- Amobarbital + Ethinyl estradiol-drospirenone شدید
تداخلات دیگر Griseofulvin
پرسش‌های متداول
Can I take Ethinyl estradiol-drospirenone with Griseofulvin?
MediHelp rates the interaction as major. Ethinyl estradiol-drospirenone and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Griseofulvin has been associated with breakthrough bleeding, menstrual irregularities and reduced reliability of combined oral contraceptives. Contraceptive failure and unintended pregnancy are possible, which is especially important because griseofulvin is potentially teratogenic.
How serious is the interaction between Ethinyl estradiol-drospirenone and Griseofulvin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Add a reliable non-hormonal barrier method throughout griseofulvin therapy and for at least one month after stopping. Consider an alternative antifungal where possible.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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