تداخل‌های دارویی
Cyclosporin + Red yeast rice
شدت: شدید
Cyclosporin and Red yeast rice: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Red yeast rice contains monacolin K, chemically identical to lovastatin, so cyclosporine can raise statin exposure and the risk of myopathy and rhabdomyolysis. Product content is variable and unregulated, which makes the exposure unpredictable.
معنای این تداخل به زبان ساده
Cyclosporin and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Red yeast rice belongs to Gastrointestinal Tract.
چرا رخ می‌دهد
Cyclosporine inhibits CYP3A4 and OATP-mediated disposition of monacolin K (lovastatin), increasing its systemic levels.
اقدام لازم
Avoid red yeast rice in patients taking cyclosporine and use a prescribed statin with labeled dose limits if lipid lowering is needed. Report muscle pain or dark urine promptly.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Cyclosporin و Red yeast rice، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۷ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin منع مصرف
- Aliskiren + Cyclosporin منع مصرف
- Bcg vaccine live + Cyclosporin منع مصرف
- Bosentan + Cyclosporin منع مصرف
- Cidofovir + Cyclosporin منع مصرف
- Cyclosporin + Dengue vaccine منع مصرف
تداخلات دیگر Red yeast rice
- Red yeast rice + Ritonavir منع مصرف
- Red yeast rice + Saquinavir منع مصرف
- Red yeast rice + Tipranavir منع مصرف
- Atazanavir + Red yeast rice شدید
- Atorvastatin + Red yeast rice شدید
- Conivaptan + Red yeast rice شدید
پرسش‌های متداول
Can I take Cyclosporin with Red yeast rice?
MediHelp rates the interaction as major. Cyclosporin and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Red yeast rice contains monacolin K, chemically identical to lovastatin, so cyclosporine can raise statin exposure and the risk of myopathy and rhabdomyolysis. Product content is variable and unregulated, which makes the exposure unpredictable.
How serious is the interaction between Cyclosporin and Red yeast rice?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid red yeast rice in patients taking cyclosporine and use a prescribed statin with labeled dose limits if lipid lowering is needed. Report muscle pain or dark urine promptly.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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