تداخل‌های دارویی
Dexamethasone + Mifepristone
شدت: منع مصرف
Dexamethasone and Mifepristone: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Mifepristone is a glucocorticoid receptor antagonist, so it can block the effect of dexamethasone and precipitate adrenal insufficiency in patients who depend on corticosteroid therapy. Reduced corticosteroid effect may also worsen the underlying condition being treated.
معنای این تداخل به زبان ساده
Dexamethasone and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dexamethasone belongs to Endocrine; Mifepristone belongs to Endocrine.
چرا رخ می‌دهد
Glucocorticoid receptor antagonism by mifepristone opposes corticosteroid effect
اقدام لازم
Mifepristone labelling contraindicates it in patients on long-term corticosteroids; avoid, or use an alternative route and monitor for adrenal insufficiency symptoms.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Dexamethasone و Mifepristone، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Dexamethasone
- Bcg vaccine live + Dexamethasone منع مصرف
- Dexamethasone + Rilpivirine منع مصرف
- Dexamethasone + Smallpox vaccine live منع مصرف
- Dexamethasone + Varicella virus vaccine live منع مصرف
- Dexamethasone + Yellow fever vaccine منع مصرف
- Dexamethasone + Zoster vaccine live منع مصرف
تداخلات دیگر Mifepristone
- Apixaban + Mifepristone منع مصرف
- Argatroban + Mifepristone منع مصرف
- Cisapride + Mifepristone منع مصرف
- Cortisone + Mifepristone منع مصرف
- Cyclosporin + Mifepristone منع مصرف
- Dabigatran etexilate + Mifepristone منع مصرف
پرسش‌های متداول
Can I take Dexamethasone with Mifepristone?
MediHelp rates the interaction as contraindicated. Dexamethasone and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mifepristone is a glucocorticoid receptor antagonist, so it can block the effect of dexamethasone and precipitate adrenal insufficiency in patients who depend on corticosteroid therapy. Reduced corticosteroid effect may also worsen the underlying condition being treated.
How serious is the interaction between Dexamethasone and Mifepristone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Mifepristone labelling contraindicates it in patients on long-term corticosteroids; avoid, or use an alternative route and monitor for adrenal insufficiency symptoms.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Rilpivirine, Smallpox vaccine live. The full list is on the Dexamethasone page.
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