تداخل‌های دارویی
Dexamethasone-tobramycin + Pancuronium
شدت: شدید
Dexamethasone-tobramycin and Pancuronium: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Aminoglycosides such as tobramycin can potentiate non-depolarizing neuromuscular blockers, causing prolonged paralysis and respiratory depression. This is clinically relevant mainly with systemic tobramycin, not with topical or ophthalmic use.
معنای این تداخل به زبان ساده
Dexamethasone-tobramycin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone-tobramycin belongs to Anti Bacterial; Pancuronium belongs to Musculoskeletal.
چرا رخ می‌دهد
Tobramycin reduces presynaptic acetylcholine release and has postsynaptic effects, adding to neuromuscular blockade.
اقدام لازم
If systemic tobramycin is used perioperatively, monitor neuromuscular function with train-of-four and be prepared for prolonged ventilatory support. Reduce the blocker dose as needed.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Dexamethasone-tobramycin و Pancuronium، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Dexamethasone-tobramycin
تداخلات دیگر Pancuronium
پرسش‌های متداول
Can I take Dexamethasone-tobramycin with Pancuronium?
MediHelp rates the interaction as major. Dexamethasone-tobramycin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aminoglycosides such as tobramycin can potentiate non-depolarizing neuromuscular blockers, causing prolonged paralysis and respiratory depression. This is clinically relevant mainly with systemic tobramycin, not with topical or ophthalmic use.
How serious is the interaction between Dexamethasone-tobramycin and Pancuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If systemic tobramycin is used perioperatively, monitor neuromuscular function with train-of-four and be prepared for prolonged ventilatory support. Reduce the blocker dose as needed.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
