تداخل‌های دارویی
Colistin + Pancuronium
شدت: شدید
Colistin and Pancuronium: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Colistin (polymyxin E) has neuromuscular blocking effects and can markedly potentiate pancuronium. Prolonged paralysis and respiratory arrest are possible, and reversal with anticholinesterases or calcium may be incomplete.
معنای این تداخل به زبان ساده
Colistin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Colistin belongs to Anti Bacterial; Pancuronium belongs to Musculoskeletal.
چرا رخ می‌دهد
Additive neuromuscular blockade, as colistin inhibits presynaptic acetylcholine release and has postsynaptic effects.
اقدام لازم
Avoid combined use where possible; if needed, reduce pancuronium dose and monitor with train-of-four. Ensure ventilatory support is available, especially in patients with renal impairment.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Colistin و Pancuronium، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Pancuronium
تداخلات دیگر Colistin
پرسش‌های متداول
Can I take Colistin with Pancuronium?
MediHelp rates the interaction as major. Colistin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Colistin (polymyxin E) has neuromuscular blocking effects and can markedly potentiate pancuronium. Prolonged paralysis and respiratory arrest are possible, and reversal with anticholinesterases or calcium may be incomplete.
How serious is the interaction between Colistin and Pancuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use where possible; if needed, reduce pancuronium dose and monitor with train-of-four. Ensure ventilatory support is available, especially in patients with renal impairment.
What other medicines interact with Pancuronium?
MediHelp also lists interactions of Pancuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Pancuronium page.
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