تداخل‌های دارویی
Dexlansoprazole + Domperidone
شدت: متوسط
Dexlansoprazole and Domperidone: moderate interaction.
آخرین به‌روزرسانی منابع: US FDA label
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Prolonged proton pump inhibitor use can cause hypomagnesemia and secondary hypokalemia or hypocalcemia, which increase vulnerability to QT prolongation and torsades de pointes. Domperidone has a dose-related QT-prolonging effect, so electrolyte depletion raises its arrhythmic risk. Risk is highest in older patients, those with cardiac disease and those taking other QT-prolonging drugs or diuretics.
معنای این تداخل به زبان ساده
Dexlansoprazole and Domperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexlansoprazole belongs to Gastrointestinal Tract; Domperidone belongs to Gastrointestinal Tract.
چرا رخ می‌دهد
Pharmacodynamic: PPI-induced hypomagnesemia (and secondary hypokalemia) potentiates the QTc-prolonging effect of domperidone. No relevant pharmacokinetic interaction is expected.
اقدام لازم
Use the lowest effective domperidone dose for the shortest time and correct magnesium, potassium and calcium before starting. Recheck magnesium periodically in patients on long-term PPI therapy, particularly if they also take diuretics or digoxin.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Dexlansoprazole و Domperidone، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
منابع
- Dexilant (dexlansoprazole) Prescribing Information - Warnings and Precautions: Hypomagnesemia — FDA Label
- Domperidone Summary of Product Characteristics — EMA SmPC
تداخلات دیگر Domperidone
- Azithromycin + Domperidone منع مصرف
- Domperidone + Erythromycin منع مصرف
- Domperidone + Lansoprazole متوسط
- Domperidone + Pantoprazole متوسط
- Domperidone + Polyethylene Glycol 3350 متوسط
- Domperidone + Rabeprazole متوسط
تداخلات دیگر Dexlansoprazole
پرسش‌های متداول
Can I take Dexlansoprazole with Domperidone?
MediHelp rates the interaction as moderate. Dexlansoprazole and Domperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prolonged proton pump inhibitor use can cause hypomagnesemia and secondary hypokalemia or hypocalcemia, which increase vulnerability to QT prolongation and torsades de pointes. Domperidone has a dose-related QT-prolonging effect, so electrolyte depletion raises its arrhythmic risk. Risk is highest in older patients, those with cardiac disease and those taking other QT-prolonging drugs or diuretics.
How serious is the interaction between Dexlansoprazole and Domperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective domperidone dose for the shortest time and correct magnesium, potassium and calcium before starting. Recheck magnesium periodically in patients on long-term PPI therapy, particularly if they also take diuretics or digoxin.
What other medicines interact with Domperidone?
MediHelp also lists interactions of Domperidone with, for example, Azithromycin, Erythromycin, Lansoprazole. The full list is on the Domperidone page.
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