تداخل‌های دارویی
Domperidone + Pantoprazole
شدت: متوسط
Domperidone and Pantoprazole: moderate interaction.
آخرین به‌روزرسانی منابع: US FDA label
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Prolonged pantoprazole use can cause hypomagnesaemia, and low magnesium or potassium increases susceptibility to QT prolongation and torsades de pointes with domperidone. This is an indirect, risk-factor-based interaction and is mainly relevant with long-term PPI use. Patients with cardiac disease, older patients and those taking diuretics are at higher risk.
معنای این تداخل به زبان ساده
Domperidone and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Domperidone belongs to Gastrointestinal Tract; Pantoprazole belongs to Gastrointestinal Tract.
چرا رخ می‌دهد
Pharmacodynamic: PPI-induced hypomagnesaemia, often with hypokalaemia, lowers the threshold for domperidone-related QTc prolongation.
اقدام لازم
Use the lowest effective domperidone dose for the shortest time. Check serum magnesium and potassium, particularly if PPI therapy has lasted more than about 3 months or the patient takes diuretics or digoxin, and correct deficits.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Domperidone و Pantoprazole، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
منابع
- Motilium (domperidone) Summary of Product Characteristics — EMA SmPC
- Protonix (pantoprazole) Prescribing Information - Warnings: Hypomagnesemia — FDA Label
تداخلات دیگر Domperidone
تداخلات دیگر Pantoprazole
پرسش‌های متداول
Can I take Domperidone with Pantoprazole?
MediHelp rates the interaction as moderate. Domperidone and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prolonged pantoprazole use can cause hypomagnesaemia, and low magnesium or potassium increases susceptibility to QT prolongation and torsades de pointes with domperidone. This is an indirect, risk-factor-based interaction and is mainly relevant with long-term PPI use. Patients with cardiac disease, older patients and those taking diuretics are at higher risk.
How serious is the interaction between Domperidone and Pantoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective domperidone dose for the shortest time. Check serum magnesium and potassium, particularly if PPI therapy has lasted more than about 3 months or the patient takes diuretics or digoxin, and correct deficits.
What other medicines interact with Domperidone?
MediHelp also lists interactions of Domperidone with, for example, Azithromycin, Erythromycin, Dexlansoprazole. The full list is on the Domperidone page.
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