تداخل‌های دارویی
Dexmethylphenidate + Safinamide
شدت: منع مصرف
Dexmethylphenidate and Safinamide: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Safinamide is a MAO-B inhibitor and dexmethylphenidate is a CNS stimulant that raises synaptic dopamine and norepinephrine. Combining them can precipitate a hypertensive crisis and hyperadrenergic or serotonergic toxicity. The labeling of both classes advises against concurrent use.
معنای این تداخل به زبان ساده
Dexmethylphenidate and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dexmethylphenidate belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
چرا رخ می‌دهد
MAO inhibition reduces catecholamine breakdown while the stimulant increases catecholamine release and blocks reuptake, producing additive sympathomimetic effects.
اقدام لازم
Do not co-administer; allow a washout of at least 14 days after stopping safinamide before starting dexmethylphenidate. Choose a non-interacting alternative for ADHD.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Dexmethylphenidate و Safinamide، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Safinamide
- Amitriptyline + Safinamide منع مصرف
- Amoxapine + Safinamide منع مصرف
- Amphetamine polistirex + Safinamide منع مصرف
- Clomipramine + Safinamide منع مصرف
- Cyclobenzaprine + Safinamide منع مصرف
- Desipramine + Safinamide منع مصرف
تداخلات دیگر Dexmethylphenidate
- Dexmethylphenidate + Isocarboxazid منع مصرف
- Dexmethylphenidate + Linezolid منع مصرف
- Dexmethylphenidate + Phenelzine منع مصرف
- Dexmethylphenidate + Procarbazine منع مصرف
- Dexmethylphenidate + Rasagiline منع مصرف
- Dexmethylphenidate + Selegiline منع مصرف
پرسش‌های متداول
Can I take Dexmethylphenidate with Safinamide?
MediHelp rates the interaction as contraindicated. Dexmethylphenidate and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide is a MAO-B inhibitor and dexmethylphenidate is a CNS stimulant that raises synaptic dopamine and norepinephrine. Combining them can precipitate a hypertensive crisis and hyperadrenergic or serotonergic toxicity. The labeling of both classes advises against concurrent use.
How serious is the interaction between Dexmethylphenidate and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; allow a washout of at least 14 days after stopping safinamide before starting dexmethylphenidate. Choose a non-interacting alternative for ADHD.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
