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تداخل‌های دارویی

Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df

شدت: منع مصرف

Didanosine and Elvitegravir / cobicistat / emtricitabine / tenofovir df: contraindicated interaction.

آخرین به‌روزرسانی

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خلاصه

This fixed-dose product is a complete HIV regimen and is not intended for use with other antiretrovirals. Tenofovir also raises didanosine exposure, increasing risks of pancreatitis, neuropathy and lactic acidosis, and can blunt CD4 recovery.

معنای این تداخل به زبان ساده

Didanosine and Elvitegravir / cobicistat / emtricitabine / tenofovir df are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

سطح شواهد: High

چرا رخ می‌دهد

Tenofovir increases didanosine concentrations, with additive mitochondrial toxicity and duplicate nucleoside therapy.

اقدام لازم

Do not co-administer; stop didanosine if the single-tablet regimen is used and select an alternative regimen if didanosine is essential.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Didanosine و Elvitegravir / cobicistat / emtricitabine / tenofovir df، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Didanosine with Elvitegravir / cobicistat / emtricitabine / tenofovir df?

MediHelp rates the interaction as contraindicated. Didanosine and Elvitegravir / cobicistat / emtricitabine / tenofovir df are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. This fixed-dose product is a complete HIV regimen and is not intended for use with other antiretrovirals. Tenofovir also raises didanosine exposure, increasing risks of pancreatitis, neuropathy and lactic acidosis, and can blunt CD4 recovery.

How serious is the interaction between Didanosine and Elvitegravir / cobicistat / emtricitabine / tenofovir df?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; stop didanosine if the single-tablet regimen is used and select an alternative regimen if didanosine is essential.

What other medicines interact with Didanosine?

MediHelp also lists interactions of Didanosine with, for example, Hydroxycarbamide, Hydroxyurea, Ribavirin. The full list is on the Didanosine page.

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