تداخل‌های دارویی
Didanosine + Stavudine
شدت: منع مصرف
Didanosine and Stavudine: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Combining these two nucleoside analogues markedly raises the risk of pancreatitis, peripheral neuropathy and lactic acidosis with hepatic steatosis. Fatal cases have been reported, particularly in pregnant women.
معنای این تداخل به زبان ساده
Didanosine and Stavudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Didanosine belongs to Anti Virals; Stavudine belongs to Anti Virals.
چرا رخ می‌دهد
Additive mitochondrial toxicity from inhibition of mitochondrial DNA polymerase gamma.
اقدام لازم
Avoid the combination and use a safer nucleoside backbone. If already on it, switch promptly and monitor for symptoms of pancreatitis, neuropathy and lactic acidosis.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Didanosine و Stavudine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Stavudine
تداخلات دیگر Didanosine
پرسش‌های متداول
Can I take Didanosine with Stavudine?
MediHelp rates the interaction as contraindicated. Didanosine and Stavudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining these two nucleoside analogues markedly raises the risk of pancreatitis, peripheral neuropathy and lactic acidosis with hepatic steatosis. Fatal cases have been reported, particularly in pregnant women.
How serious is the interaction between Didanosine and Stavudine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a safer nucleoside backbone. If already on it, switch promptly and monitor for symptoms of pancreatitis, neuropathy and lactic acidosis.
What other medicines interact with Stavudine?
MediHelp also lists interactions of Stavudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Zidovudine. The full list is on the Stavudine page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
