تداخل‌های دارویی
Didanosine + Valganciclovir
شدت: شدید
Didanosine and Valganciclovir: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Valganciclovir is converted to ganciclovir, which can raise didanosine exposure and add to the toxicity of didanosine, including pancreatitis, neuropathy and cytopenias. Co-administration therefore carries an increased risk of serious adverse effects.
معنای این تداخل به زبان ساده
Didanosine and Valganciclovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Didanosine belongs to Anti Virals; Valganciclovir belongs to Anti Virals.
چرا رخ می‌دهد
Ganciclovir increases didanosine exposure through a pharmacokinetic effect and adds to its toxicity; hematologic effects are additive.
اقدام لازم
Avoid the combination where alternatives exist. If used, monitor for pancreatitis, neuropathy and blood count changes, and reduce the didanosine dose as per labeling.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Didanosine و Valganciclovir، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Valganciclovir
تداخلات دیگر Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df منع مصرف
- Didanosine + Hydroxycarbamide منع مصرف
- Didanosine + Hydroxyurea منع مصرف
- Didanosine + Ribavirin منع مصرف
- Didanosine + Stavudine منع مصرف
- Allopurinol + Didanosine شدید
پرسش‌های متداول
Can I take Didanosine with Valganciclovir?
MediHelp rates the interaction as major. Didanosine and Valganciclovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Valganciclovir is converted to ganciclovir, which can raise didanosine exposure and add to the toxicity of didanosine, including pancreatitis, neuropathy and cytopenias. Co-administration therefore carries an increased risk of serious adverse effects.
How serious is the interaction between Didanosine and Valganciclovir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where alternatives exist. If used, monitor for pancreatitis, neuropathy and blood count changes, and reduce the didanosine dose as per labeling.
What other medicines interact with Valganciclovir?
MediHelp also lists interactions of Valganciclovir with, for example, Ganciclovir, Liposomal doxorubicin, Maribavir. The full list is on the Valganciclovir page.
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