Drug interactions
domperidone + pantoprazole
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Chronic PPI therapy can cause hypomagnesemia, which may potentiate domperidone-associated QT prolongation and torsades de pointes risk.
Mechanism of action
Pharmacodynamic: PPI-induced hypomagnesemia increases susceptibility to QTc prolongation from domperidone.
Clinical management
If coadministered, use the lowest effective domperidone dose/shortest duration; monitor serum magnesium (and potassium) periodically, especially if PPI use >3 months; consider baseline/interval ECG in patients with risk factors; correct electrolytes.
Drug reference
References
- Domperidone (Motilium) – Summary of Product Characteristics — EMA
- Pantoprazole – Prescribing Information (hypomagnesemia warning) — FDA Label
- Domperidone: Drug Interactions — Lexicomp
Frequently asked questions
Can I take domperidone with pantoprazole?
The interaction is rated: Moderate. Chronic PPI therapy can cause hypomagnesemia, which may potentiate domperidone-associated QT prolongation and torsades de pointes risk.
How serious is the interaction between domperidone and pantoprazole?
The interaction is rated: Moderate. Evidence level: Moderate.
How is the interaction between domperidone and pantoprazole managed?
If coadministered, use the lowest effective domperidone dose/shortest duration; monitor serum magnesium (and potassium) periodically, especially if PPI use >3 months; consider baseline/interval ECG in patients with risk factors; correct electrolytes.
Why do domperidone and pantoprazole interact?
Pharmacodynamic: PPI-induced hypomagnesemia increases susceptibility to QTc prolongation from domperidone.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.