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تداخل‌های دارویی

Hydrocodone + Isocarboxazid

شدت: منع مصرف

Hydrocodone and Isocarboxazid: contraindicated interaction.

آخرین به‌روزرسانی

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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

MAO inhibitors given with opioids can cause serotonin syndrome or unpredictable opioid toxicity, including respiratory depression and coma. The risk persists for about two weeks after the MAOI is stopped.

معنای این تداخل به زبان ساده

Hydrocodone and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Hydrocodone belongs to Musculoskeletal; Isocarboxazid belongs to Central Nervous System.

سطح شواهد: Moderate

چرا رخ می‌دهد

Nonselective MAO inhibition raises serotonergic and noradrenergic activity and may alter opioid effects, causing serotonin toxicity or CNS depression.

اقدام لازم

Do not use hydrocodone during or within 14 days of an MAOI; choose a non-opioid or non-interacting analgesic. If an opioid is unavoidable, use closely monitored small test doses.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Hydrocodone و Isocarboxazid، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Hydrocodone with Isocarboxazid?

MediHelp rates the interaction as contraindicated. Hydrocodone and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MAO inhibitors given with opioids can cause serotonin syndrome or unpredictable opioid toxicity, including respiratory depression and coma. The risk persists for about two weeks after the MAOI is stopped.

How serious is the interaction between Hydrocodone and Isocarboxazid?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use hydrocodone during or within 14 days of an MAOI; choose a non-opioid or non-interacting analgesic. If an opioid is unavoidable, use closely monitored small test doses.

What other medicines interact with Hydrocodone?

MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Olanzapine / samidorphan. The full list is on the Hydrocodone page.

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