تداخل‌های دارویی
Hydroxyurea + Stavudine
شدت: شدید
Hydroxyurea and Stavudine: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
In HIV patients, hydroxyurea combined with stavudine has been associated with pancreatitis, hepatotoxicity and peripheral neuropathy, sometimes fatal. The overlapping toxicities make the combination hazardous.
معنای این تداخل به زبان ساده
Hydroxyurea and Stavudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydroxyurea belongs to Miscellaneous; Stavudine belongs to Anti Virals.
چرا رخ می‌دهد
Overlapping pancreatic, hepatic and neurotoxic effects; the precise mechanism is not fully established.
اقدام لازم
Avoid the combination and choose an antiretroviral without these overlapping toxicities. If it was used, stop and evaluate promptly for pancreatitis, liver injury or neuropathy.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Hydroxyurea و Stavudine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Stavudine
تداخلات دیگر Hydroxyurea
پرسش‌های متداول
Can I take Hydroxyurea with Stavudine?
MediHelp rates the interaction as major. Hydroxyurea and Stavudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. In HIV patients, hydroxyurea combined with stavudine has been associated with pancreatitis, hepatotoxicity and peripheral neuropathy, sometimes fatal. The overlapping toxicities make the combination hazardous.
How serious is the interaction between Hydroxyurea and Stavudine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antiretroviral without these overlapping toxicities. If it was used, stop and evaluate promptly for pancreatitis, liver injury or neuropathy.
What other medicines interact with Stavudine?
MediHelp also lists interactions of Stavudine with, for example, Didanosine, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide. The full list is on the Stavudine page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
