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تداخل‌های دارویی

Isocarboxazid + Palonosetron

شدت: شدید

Isocarboxazid and Palonosetron: major interaction.

آخرین به‌روزرسانی

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خلاصه

Non-selective MAO inhibitors markedly raise serotonin availability, and adding a 5-HT3 antagonist has been linked to serotonin syndrome in rare reports. Because the MAOI baseline risk is high, the combination warrants more caution.

معنای این تداخل به زبان ساده

Isocarboxazid and Palonosetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Isocarboxazid belongs to Central Nervous System; Palonosetron belongs to Gastrointestinal Tract.

سطح شواهد: Low

چرا رخ می‌دهد

Irreversible MAO inhibition increases serotonin, with possible additive serotonergic effects from the antiemetic.

اقدام لازم

Prefer a non-serotonergic antiemetic where feasible; if used, give the lowest dose and monitor closely for serotonin syndrome. Stop both drugs and treat if it occurs.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Isocarboxazid و Palonosetron، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Isocarboxazid with Palonosetron?

MediHelp rates the interaction as major. Isocarboxazid and Palonosetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Non-selective MAO inhibitors markedly raise serotonin availability, and adding a 5-HT3 antagonist has been linked to serotonin syndrome in rare reports. Because the MAOI baseline risk is high, the combination warrants more caution.

How serious is the interaction between Isocarboxazid and Palonosetron?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-serotonergic antiemetic where feasible; if used, give the lowest dose and monitor closely for serotonin syndrome. Stop both drugs and treat if it occurs.

What other medicines interact with Palonosetron?

MediHelp also lists interactions of Palonosetron with, for example, Apomorphine, Phenelzine, Tranylcypromine. The full list is on the Palonosetron page.

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