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Palonosetron + Tranylcypromine

شدت: شدید

Palonosetron and Tranylcypromine: major interaction.

آخرین به‌روزرسانی

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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Tranylcypromine is an irreversible nonselective MAO inhibitor that markedly raises serotonin availability. Adding a 5-HT3 antagonist such as palonosetron may contribute to serotonin syndrome, though reports for palonosetron are limited.

معنای این تداخل به زبان ساده

Palonosetron and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Palonosetron belongs to Gastrointestinal Tract; Tranylcypromine belongs to Central Nervous System.

سطح شواهد: Low

چرا رخ می‌دهد

Additive serotonergic effects on top of irreversible MAO inhibition; the contribution of 5-HT3 antagonists is not firmly established.

اقدام لازم

Prefer an antiemetic from another class where possible. If palonosetron is needed, monitor closely for serotonin syndrome after administration.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Palonosetron و Tranylcypromine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Palonosetron with Tranylcypromine?

MediHelp rates the interaction as major. Palonosetron and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tranylcypromine is an irreversible nonselective MAO inhibitor that markedly raises serotonin availability. Adding a 5-HT3 antagonist such as palonosetron may contribute to serotonin syndrome, though reports for palonosetron are limited.

How serious is the interaction between Palonosetron and Tranylcypromine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antiemetic from another class where possible. If palonosetron is needed, monitor closely for serotonin syndrome after administration.

What other medicines interact with Palonosetron?

MediHelp also lists interactions of Palonosetron with, for example, Apomorphine, Isocarboxazid, Phenelzine. The full list is on the Palonosetron page.

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