تداخل‌های دارویی
Lycopus + Methimazole
شدت: متوسط
Lycopus and Methimazole: moderate interaction.
آخرین به‌روزرسانی
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Lycopus (gypsywort) extracts have antithyrotropic activity and may reduce thyroid hormone activity, including peripheral T4 to T3 conversion. Combined with methimazole this could add to the antithyroid effect and raise the risk of over-suppression and hypothyroidism.
معنای این تداخل به زبان ساده
Lycopus and Methimazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
چرا رخ می‌دهد
Additive antithyroid pharmacodynamic effects, with lycopus inhibiting TSH binding and peripheral T4 to T3 conversion.
اقدام لازم
Avoid starting lycopus in patients on methimazole where possible. If it is used, monitor TSH and free T4/T3 every 4-6 weeks and reduce the methimazole dose if hypothyroidism appears.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Lycopus و Methimazole، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Methimazole
پرسش‌های متداول
Can I take Lycopus with Methimazole?
MediHelp rates the interaction as moderate. Lycopus and Methimazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lycopus (gypsywort) extracts have antithyrotropic activity and may reduce thyroid hormone activity, including peripheral T4 to T3 conversion. Combined with methimazole this could add to the antithyroid effect and raise the risk of over-suppression and hypothyroidism.
How serious is the interaction between Lycopus and Methimazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting lycopus in patients on methimazole where possible. If it is used, monitor TSH and free T4/T3 every 4-6 weeks and reduce the methimazole dose if hypothyroidism appears.
What other medicines interact with Methimazole?
MediHelp also lists interactions of Methimazole with, for example, Carbamazepine, Clozapine, Propylthiouracil. The full list is on the Methimazole page.
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