تداخل‌های دارویی
Methimazole + Propylthiouracil
شدت: شدید
Methimazole and Propylthiouracil: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Both are thionamide antithyroid drugs with the same therapeutic action, so combining them offers no benefit. Each carries a risk of agranulocytosis, hepatotoxicity and other adverse effects, and duplication may add to this risk.
معنای این تداخل به زبان ساده
Methimazole and Propylthiouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Methimazole belongs to Endocrine; Propylthiouracil belongs to Endocrine.
چرا رخ می‌دهد
Therapeutic duplication with additive adverse effects, including myelosuppression, from two thionamides.
اقدام لازم
Avoid concurrent use; use a single thionamide and monitor blood counts and liver function, with prompt evaluation of fever or sore throat.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Methimazole و Propylthiouracil، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Propylthiouracil
تداخلات دیگر Methimazole
پرسش‌های متداول
Can I take Methimazole with Propylthiouracil?
MediHelp rates the interaction as major. Methimazole and Propylthiouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are thionamide antithyroid drugs with the same therapeutic action, so combining them offers no benefit. Each carries a risk of agranulocytosis, hepatotoxicity and other adverse effects, and duplication may add to this risk.
How serious is the interaction between Methimazole and Propylthiouracil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; use a single thionamide and monitor blood counts and liver function, with prompt evaluation of fever or sore throat.
What other medicines interact with Propylthiouracil?
MediHelp also lists interactions of Propylthiouracil with, for example, Carbamazepine, Clozapine, Pexidartinib. The full list is on the Propylthiouracil page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
