تداخل‌های دارویی
Methimazole + Sodium iodide i-131
شدت: شدید
Methimazole and Sodium iodide i-131: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Antithyroid drugs reduce thyroid uptake of radioiodine, so the therapeutic radiation dose delivered to the gland may be inadequate. Treatment failure or the need for repeat dosing may result.
معنای این تداخل به زبان ساده
Methimazole and Sodium iodide i-131 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
چرا رخ می‌دهد
Methimazole inhibits thyroid peroxidase and hormone synthesis, which lowers thyroidal radioiodine uptake and retention.
اقدام لازم
Stop methimazole several days before I-131 administration, typically 3 to 4 days per labeling, and do not give them together. Restart afterward according to the treating specialist's plan and monitor thyroid function.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Methimazole و Sodium iodide i-131، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Methimazole
پرسش‌های متداول
Can I take Methimazole with Sodium iodide i-131?
MediHelp rates the interaction as major. Methimazole and Sodium iodide i-131 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antithyroid drugs reduce thyroid uptake of radioiodine, so the therapeutic radiation dose delivered to the gland may be inadequate. Treatment failure or the need for repeat dosing may result.
How serious is the interaction between Methimazole and Sodium iodide i-131?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop methimazole several days before I-131 administration, typically 3 to 4 days per labeling, and do not give them together. Restart afterward according to the treating specialist's plan and monitor thyroid function.
What other medicines interact with Methimazole?
MediHelp also lists interactions of Methimazole with, for example, Carbamazepine, Clozapine, Propylthiouracil. The full list is on the Methimazole page.
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