تداخل‌های دارویی
Measles mumps and rubella vaccine + Tisagenlecleucel
شدت: منع مصرف
Measles mumps and rubella vaccine and Tisagenlecleucel: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Tisagenlecleucel is a CAR-T cell therapy given after lymphodepleting chemotherapy and is associated with B-cell aplasia and prolonged immune suppression. Live vaccines can cause disseminated vaccine-strain infection in this setting.
معنای این تداخل به زبان ساده
Measles mumps and rubella vaccine and Tisagenlecleucel are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Measles mumps and rubella vaccine belongs to Miscellaneous; Tisagenlecleucel belongs to Oncology.
چرا رخ می‌دهد
Pharmacodynamic: lymphodepleting chemotherapy and CAR-T mediated B-cell depletion impair control of replicating live vaccine viruses.
اقدام لازم
Do not give live vaccines from at least 6 weeks before lymphodepletion, during treatment, and until immune recovery is confirmed. Give inactivated vaccines according to specialist guidance after immune reconstitution.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Measles mumps and rubella vaccine و Tisagenlecleucel، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine منع مصرف
- Anakinra + Measles mumps and rubella vaccine منع مصرف
- Antithymocyte globulin equine + Measles mumps and rubella vaccine منع مصرف
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine منع مصرف
- Azathioprine + Measles mumps and rubella vaccine منع مصرف
- Basiliximab + Measles mumps and rubella vaccine منع مصرف
تداخلات دیگر Tisagenlecleucel
پرسش‌های متداول
Can I take Measles mumps and rubella vaccine with Tisagenlecleucel?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine and Tisagenlecleucel are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tisagenlecleucel is a CAR-T cell therapy given after lymphodepleting chemotherapy and is associated with B-cell aplasia and prolonged immune suppression. Live vaccines can cause disseminated vaccine-strain infection in this setting.
How serious is the interaction between Measles mumps and rubella vaccine and Tisagenlecleucel?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live vaccines from at least 6 weeks before lymphodepletion, during treatment, and until immune recovery is confirmed. Give inactivated vaccines according to specialist guidance after immune reconstitution.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
