تداخل‌های دارویی
Azathioprine + Tisagenlecleucel
شدت: شدید
Azathioprine and Tisagenlecleucel: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Azathioprine may impair CAR T-cell expansion and persistence, potentially reducing efficacy of tisagenlecleucel. Together they also add to infection risk in patients already immunocompromised.
معنای این تداخل به زبان ساده
Azathioprine and Tisagenlecleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azathioprine belongs to Gastrointestinal Tract; Tisagenlecleucel belongs to Oncology.
چرا رخ می‌دهد
Antimetabolite-driven lymphocyte suppression may blunt CAR T-cell proliferation, and the effects add to the immune deficiency caused by the therapy.
اقدام لازم
Avoid azathioprine around lymphodepletion and CAR T infusion unless essential, and follow the product labeling for washout. Monitor closely for infection and cytopenias if it must be used.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Azathioprine و Tisagenlecleucel، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine منع مصرف
- Azathioprine + Bcg vaccine live منع مصرف
- Azathioprine + Febuxostat منع مصرف
- Azathioprine + Influenza virus vaccine quadrivalent intranasal منع مصرف
- Azathioprine + Measles mumps and rubella vaccine منع مصرف
- Azathioprine + Measles mumps and rubella vaccine live منع مصرف
تداخلات دیگر Tisagenlecleucel
پرسش‌های متداول
Can I take Azathioprine with Tisagenlecleucel?
MediHelp rates the interaction as major. Azathioprine and Tisagenlecleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Azathioprine may impair CAR T-cell expansion and persistence, potentially reducing efficacy of tisagenlecleucel. Together they also add to infection risk in patients already immunocompromised.
How serious is the interaction between Azathioprine and Tisagenlecleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid azathioprine around lymphodepletion and CAR T infusion unless essential, and follow the product labeling for washout. Monitor closely for infection and cytopenias if it must be used.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
