تداخل‌های دارویی
Methimazole + Phenindione
شدت: متوسط
Methimazole and Phenindione: moderate interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Correcting hyperthyroidism with methimazole slows the catabolism of vitamin K-dependent clotting factors. As a result the anticoagulant effect of vitamin K antagonists such as phenindione tends to fall as the patient becomes euthyroid. Starting or stopping methimazole can therefore change INR control.
معنای این تداخل به زبان ساده
Methimazole and Phenindione can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
چرا رخ می‌دهد
Normalization of thyroid state reduces clotting factor turnover, which diminishes the response to vitamin K antagonists.
اقدام لازم
Monitor INR more frequently when methimazole is started, changed or stopped. Adjust the phenindione dose to maintain the target INR.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Methimazole و Phenindione، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Methimazole
پرسش‌های متداول
Can I take Methimazole with Phenindione?
MediHelp rates the interaction as moderate. Methimazole and Phenindione can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Correcting hyperthyroidism with methimazole slows the catabolism of vitamin K-dependent clotting factors. As a result the anticoagulant effect of vitamin K antagonists such as phenindione tends to fall as the patient becomes euthyroid. Starting or stopping methimazole can therefore change INR control.
How serious is the interaction between Methimazole and Phenindione?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more frequently when methimazole is started, changed or stopped. Adjust the phenindione dose to maintain the target INR.
What other medicines interact with Methimazole?
MediHelp also lists interactions of Methimazole with, for example, Carbamazepine, Clozapine, Propylthiouracil. The full list is on the Methimazole page.
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