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Oritavancin + Warfarin

شدت: متوسط

Oritavancin and Warfarin: moderate interaction.

آخرین به‌روزرسانی

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خلاصه

Oritavancin artificially prolongs PT/INR and aPTT in laboratory tests for hours to days after dosing, so coagulation results may not reflect true anticoagulation in warfarin-treated patients. Oritavancin may also modestly raise warfarin exposure, so true bleeding risk may be increased.

معنای این تداخل به زبان ساده

Oritavancin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Oritavancin belongs to Anti Bacterial; Warfarin belongs to Cardiovascular.

سطح شواهد: Moderate

چرا رخ می‌دهد

Oritavancin binds and interferes with phospholipid reagents used in clotting assays, and may weakly inhibit CYP2C9 and so reduce warfarin clearance.

اقدام لازم

Avoid relying on INR measurements shortly after oritavancin dosing and monitor the patient clinically for bleeding. Consider alternative anticoagulation monitoring or a different antibiotic if tight INR control is needed.

از داروساز چه بپرسید

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Oritavancin و Warfarin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Oritavancin with Warfarin?

MediHelp rates the interaction as moderate. Oritavancin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oritavancin artificially prolongs PT/INR and aPTT in laboratory tests for hours to days after dosing, so coagulation results may not reflect true anticoagulation in warfarin-treated patients. Oritavancin may also modestly raise warfarin exposure, so true bleeding risk may be increased.

How serious is the interaction between Oritavancin and Warfarin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid relying on INR measurements shortly after oritavancin dosing and monitor the patient clinically for bleeding. Consider alternative anticoagulation monitoring or a different antibiotic if tight INR control is needed.

What other medicines interact with Oritavancin?

MediHelp also lists interactions of Oritavancin with, for example, Heparin, Carbamazepine, Cyclosporin. The full list is on the Oritavancin page.

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