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تداخل‌های دارویی

Phenelzine + Trimipramine

شدت: منع مصرف

Phenelzine and Trimipramine: contraindicated interaction.

آخرین به‌روزرسانی

ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.

محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Combining a tricyclic antidepressant with a nonselective MAOI can cause serotonin syndrome and hypertensive crisis. Reactions can be severe and life-threatening.

معنای این تداخل به زبان ساده

Phenelzine and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Phenelzine belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.

سطح شواهد: High

چرا رخ می‌دهد

MAO inhibition combined with tricyclic reuptake inhibition causes excess serotonergic and noradrenergic activity.

اقدام لازم

Do not use together. Allow a washout of at least 14 days after stopping phenelzine before trimipramine, and an appropriate interval in the other direction.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Phenelzine و Trimipramine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Phenelzine with Trimipramine?

MediHelp rates the interaction as contraindicated. Phenelzine and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining a tricyclic antidepressant with a nonselective MAOI can cause serotonin syndrome and hypertensive crisis. Reactions can be severe and life-threatening.

How serious is the interaction between Phenelzine and Trimipramine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Allow a washout of at least 14 days after stopping phenelzine before trimipramine, and an appropriate interval in the other direction.

What other medicines interact with Trimipramine?

MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.

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