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تداخل‌های دارویی

Phenelzine + Venlafaxine

شدت: منع مصرف

Phenelzine and Venlafaxine: contraindicated interaction.

آخرین به‌روزرسانی

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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Venlafaxine with phenelzine can cause life-threatening serotonin syndrome, with hyperthermia, rigidity, autonomic instability and seizures. The combination is contraindicated in labeling.

معنای این تداخل به زبان ساده

Phenelzine and Venlafaxine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Phenelzine belongs to Central Nervous System; Venlafaxine belongs to Central Nervous System.

سطح شواهد: High

چرا رخ می‌دهد

Serotonin and noradrenaline reuptake inhibition combined with irreversible MAO inhibition causes monoamine excess.

اقدام لازم

Do not coadminister. Leave at least 14 days after stopping phenelzine before starting venlafaxine, and at least 7 days after stopping venlafaxine before starting phenelzine.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Phenelzine و Venlafaxine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Phenelzine with Venlafaxine?

MediHelp rates the interaction as contraindicated. Phenelzine and Venlafaxine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Venlafaxine with phenelzine can cause life-threatening serotonin syndrome, with hyperthermia, rigidity, autonomic instability and seizures. The combination is contraindicated in labeling.

How serious is the interaction between Phenelzine and Venlafaxine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Leave at least 14 days after stopping phenelzine before starting venlafaxine, and at least 7 days after stopping venlafaxine before starting phenelzine.

What other medicines interact with Venlafaxine?

MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Procarbazine. The full list is on the Venlafaxine page.

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