تداخل‌های دارویی
Polymyxin b + Rocuronium
شدت: شدید
Polymyxin b and Rocuronium: major interaction.
آخرین به‌روزرسانی
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خلاصه
Polymyxin B has neuromuscular blocking properties and can intensify and prolong rocuronium paralysis. This can lead to prolonged respiratory muscle weakness or apnea, particularly with renal dysfunction.
معنای این تداخل به زبان ساده
Polymyxin b and Rocuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Polymyxin b belongs to Anti Bacterial; Rocuronium belongs to Musculoskeletal.
چرا رخ می‌دهد
Additive neuromuscular blockade through presynaptic inhibition of acetylcholine release and reduced postsynaptic sensitivity from polymyxin B.
اقدام لازم
Avoid concurrent use where an alternative antibiotic is suitable; if needed, reduce rocuronium dose and monitor with train-of-four. Have ventilatory support ready; neostigmine reversal may be incomplete.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Polymyxin b و Rocuronium، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Rocuronium
تداخلات دیگر Polymyxin b
- Cidofovir + Polymyxin b منع مصرف
- Colistin + Polymyxin b منع مصرف
- Acyclovir + Polymyxin b شدید
- Adefovir + Polymyxin b شدید
- Amikacin + Polymyxin b شدید
- Amphotericin b + Polymyxin b شدید
پرسش‌های متداول
Can I take Polymyxin b with Rocuronium?
MediHelp rates the interaction as major. Polymyxin b and Rocuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Polymyxin B has neuromuscular blocking properties and can intensify and prolong rocuronium paralysis. This can lead to prolonged respiratory muscle weakness or apnea, particularly with renal dysfunction.
How serious is the interaction between Polymyxin b and Rocuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where an alternative antibiotic is suitable; if needed, reduce rocuronium dose and monitor with train-of-four. Have ventilatory support ready; neostigmine reversal may be incomplete.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.
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