تداخل‌های دارویی
Posaconazole + Tisotumab vedotin
شدت: متوسط
Posaconazole and Tisotumab vedotin: moderate interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
The cytotoxic payload of tisotumab vedotin, MMAE, is metabolized by CYP3A4, so a strong inhibitor like posaconazole may increase unconjugated MMAE exposure. This could heighten toxicities such as neutropenia, neuropathy and ocular events.
معنای این تداخل به زبان ساده
Posaconazole and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Tisotumab vedotin belongs to Oncology.
چرا رخ می‌دهد
Strong CYP3A4 inhibition by posaconazole reduces the clearance of released MMAE.
اقدام لازم
Monitor closely for signs of MMAE toxicity, including blood counts and neuropathy, during concomitant use. Consider an alternative antifungal where feasible.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Posaconazole و Tisotumab vedotin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۷ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Posaconazole
- Artemether + Posaconazole منع مصرف
- Avanafil + Posaconazole منع مصرف
- Cobimetinib + Posaconazole منع مصرف
- Conivaptan + Posaconazole منع مصرف
- Dihydroergotamine intranasal + Posaconazole منع مصرف
- Dihydroergotamine + Posaconazole منع مصرف
تداخلات دیگر Tisotumab vedotin
پرسش‌های متداول
Can I take Posaconazole with Tisotumab vedotin?
MediHelp rates the interaction as moderate. Posaconazole and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The cytotoxic payload of tisotumab vedotin, MMAE, is metabolized by CYP3A4, so a strong inhibitor like posaconazole may increase unconjugated MMAE exposure. This could heighten toxicities such as neutropenia, neuropathy and ocular events.
How serious is the interaction between Posaconazole and Tisotumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for signs of MMAE toxicity, including blood counts and neuropathy, during concomitant use. Consider an alternative antifungal where feasible.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
