تداخل‌های دارویی
Mifepristone + Tisotumab vedotin
شدت: متوسط
Mifepristone and Tisotumab vedotin: moderate interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
The cytotoxic payload MMAE of tisotumab vedotin is a CYP3A4 substrate, and a strong CYP3A4 inhibitor may increase its exposure. This could worsen toxicities such as neutropenia and neuropathy.
معنای این تداخل به زبان ساده
Mifepristone and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Tisotumab vedotin belongs to Oncology.
چرا رخ می‌دهد
Mifepristone inhibits CYP3A4, reducing clearance of unconjugated MMAE released from the antibody-drug conjugate.
اقدام لازم
Monitor for signs of tisotumab vedotin toxicity, including neutropenia, neuropathy and ocular effects. Consider an alternative to mifepristone when feasible.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Mifepristone و Tisotumab vedotin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۷ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Mifepristone
- Apixaban + Mifepristone منع مصرف
- Argatroban + Mifepristone منع مصرف
- Cisapride + Mifepristone منع مصرف
- Cortisone + Mifepristone منع مصرف
- Cyclosporin + Mifepristone منع مصرف
- Dabigatran etexilate + Mifepristone منع مصرف
تداخلات دیگر Tisotumab vedotin
پرسش‌های متداول
Can I take Mifepristone with Tisotumab vedotin?
MediHelp rates the interaction as moderate. Mifepristone and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The cytotoxic payload MMAE of tisotumab vedotin is a CYP3A4 substrate, and a strong CYP3A4 inhibitor may increase its exposure. This could worsen toxicities such as neutropenia and neuropathy.
How serious is the interaction between Mifepristone and Tisotumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of tisotumab vedotin toxicity, including neutropenia, neuropathy and ocular effects. Consider an alternative to mifepristone when feasible.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
