تداخلهای دارویی
Itraconazole + Tisotumab vedotin
شدت: متوسط
Itraconazole and Tisotumab vedotin: moderate interaction.
آخرین بهروزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصهای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمیشود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Itraconazole may increase unconjugated MMAE exposure from tisotumab vedotin, which may worsen adverse effects such as neutropenia and neuropathy.
معنای این تداخل به زبان ساده
Itraconazole and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Tisotumab vedotin belongs to Oncology.
چرا رخ میدهد
Strong CYP3A4 inhibition reduces the metabolism of MMAE.
اقدام لازم
Monitor for adverse reactions such as neutropenia and neuropathy during co-therapy, and manage them by dose interruption or modification.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیههای کامل مدیریت Itraconazole و Tisotumab vedotin، یادداشتهای تکمیلی، جزئیات شواهد و بررسیکننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۷ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Itraconazole
- Alfuzosin + Itraconazole منع مصرف
- Alprazolam + Itraconazole منع مصرف
- Avanafil + Itraconazole منع مصرف
- Conivaptan + Itraconazole منع مصرف
- Dihydroergotamine intranasal + Itraconazole منع مصرف
- Dihydroergotamine + Itraconazole منع مصرف
تداخلات دیگر Tisotumab vedotin
پرسشهای متداول
Can I take Itraconazole with Tisotumab vedotin?
MediHelp rates the interaction as moderate. Itraconazole and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may increase unconjugated MMAE exposure from tisotumab vedotin, which may worsen adverse effects such as neutropenia and neuropathy.
How serious is the interaction between Itraconazole and Tisotumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse reactions such as neutropenia and neuropathy during co-therapy, and manage them by dose interruption or modification.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
تکنگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.