Drug interactions
Tranylcypromine + Valbenazine
Severity: Contraindicated
Tranylcypromine and Valbenazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine is a VMAT2 inhibitor that depletes monoamines, and MAOIs raise synaptic monoamine levels. The combination may reduce valbenazine efficacy and may increase the risk of serotonin toxicity. Labeling contraindicates concomitant use with MAOIs.
What this interaction means in plain words
Tranylcypromine and Valbenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Tranylcypromine belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Why it happens
Opposing effects on monoamine disposition: VMAT2 inhibition versus MAO inhibition preventing monoamine breakdown.
What to do
Do not combine; select an alternative therapy. Observe the washout period recommended in the labeling when changing between agents.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Tranylcypromine and Valbenazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
- Cisapride + Valbenazine Major
Frequently asked questions
Can I take Tranylcypromine with Valbenazine?
MediHelp rates the interaction as contraindicated. Tranylcypromine and Valbenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Valbenazine is a VMAT2 inhibitor that depletes monoamines, and MAOIs raise synaptic monoamine levels. The combination may reduce valbenazine efficacy and may increase the risk of serotonin toxicity. Labeling contraindicates concomitant use with MAOIs.
How serious is the interaction between Tranylcypromine and Valbenazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; select an alternative therapy. Observe the washout period recommended in the labeling when changing between agents.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
