Référentiel des médicaments
Carbimazole
Carbimazole is a medicine in the class endocrine. It is used for hyperthyroidism.
- Classe médicamenteuse: Endocrine
- Indications: hyperthyroidism
Dernière mise à jour
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L'essentiel
- Classe médicamenteuse
- Endocrine
- Formes courantes
- comprimé
- Dosages courants
- 5 mg, 20 mg
- Interactions connues
- 2 (Modérée: 2)
- Noms commerciaux
- 10
- Pays et marchés
- 4
Indications
Mécanisme d'action
Its antithyroid action is due to its conversion to methimazole after absorption. It is used to treat hyperthyroidism and thyrotoxicosis. Carbimazole is an aitithyroid agent that decreases the uptake and concentration of inorganic iodine by thyroid, it also reduces the formation of di-iodotyrosine and thyroxine.
Posologie adulte habituelle (résumé de la notice)
Initial dose is in the range 20 mg to 60 mg, taken as two to three divided doses.
Grossesse et allaitement
- Grossesse
- Unsafe Suspected to cause birth defects with 1st-trimester use (scalp, gut and abdominal wall defects). Use effective contraception; in early pregnancy propylthiouracil is usually preferred. If needed later, use the lowest dose and monitor mother, fetus and newborn thyroid.
- Allaitement
- Safe Converted to methimazole, which passes into milk. UK label: do not breastfeed if treatment continues. LactMed and thyroid guidelines: moderate doses are acceptable and do not affect infant thyroid function; monitor infant growth.
Effets indésirables signalés
- Headache
- Nausea
- Angioedema
- Bone marrow depression
- Acute pancreatitis
Précautions particulières
- Patients unable to comply with the instructions for use or who cannot be monitored regularly should not be treated with carbimazole.
- Carbimazole tablets should be used with caution in patients with mild-moderate hepatic insufficiency.
- Precaution should be taken in patients with intrathoracic goitre, which may worsen during initial treatment with carbimazole
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (2)
- Carbimazole + Rosuvastatin Moderate
- Carbimazole + Tiratricol Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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Questions fréquentes
What is Carbimazole used for?
Carbimazole is a medicine in the class endocrine. It is used for Hyperthyroidism.
What side effects have been reported with Carbimazole?
Headache, Nausea, Angioedema, Bone marrow depression, Acute pancreatitis.
Can Carbimazole be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Suspected to cause birth defects with 1st-trimester use (scalp, gut and abdominal wall defects). Use effective contraception; in early pregnancy propylthiouracil is usually preferred. If needed later, use the lowest dose and monitor mother, fetus and newborn thyroid. Breastfeeding: Safe. Converted to methimazole, which passes into milk. UK label: do not breastfeed if treatment continues. LactMed and thyroid guidelines: moderate doses are acceptable and do not affect infant thyroid function; monitor infant growth.
What does Carbimazole interact with?
MediHelp lists 2 known interactions for Carbimazole. Moderate: 2. The most serious include Rosuvastatin, Tiratricol.
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