Référentiel des médicaments
Liothyronine
Liothyronine is a medicine in the class endocrine. It is used for hypothyroidism.
- Classe médicamenteuse: Endocrine
- Indications: hypothyroidism
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Endocrine
- Formes courantes
- comprimé
- Interactions connues
- 53 (Modérée: 41 · Mineure: 12)
- Noms commerciaux
- 2
- Pays et marchés
- 1
Indications
Mécanisme d'action
Thyroid hormones act by controlling DNA transcription and protein synthesis. T3 and T4 diffuse into the cell nucleus and bind to thyroid receptor proteins attached to DNA, activating gene transcription and messenger RNA synthesis.
Posologie adulte habituelle (résumé de la notice)
Hypothyroidism: start 25 mcg orally once daily; increase by 25 mcg daily every 1 or 2 weeks if needed; usual maintenance 25 mcg to 75 mcg once daily
Grossesse et allaitement
- Grossesse
- Safe Post-marketing data have not shown more birth defects or miscarriage. Untreated hypothyroidism harms mother and fetus, so do not stop treatment: check TSH and adjust the dose during pregnancy. Levothyroxine is the usual first choice in pregnancy.
- Allaitement
- Safe Liothyronine (T3) is a normal component of milk; replacement doses are not a reason to stop breastfeeding (LactMed). US label: weigh benefits (insufficient data on infant effects). Levothyroxine is recommended for hypothyroidism while breastfeeding.
Effets indésirables signalés
- Arrhythmias
- Headache
- Nervousness
- Insomnia
- Tremors
- Weight loss
Mises en garde encadrées
- Not for treatment of obesity or for weight loss. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Larger doses may produce serious or even life-threatening toxicity, particularly with sympathomimetic amines.
Contre-indications
- Uncorrected adrenal insufficiency
Précautions particulières
- Cardiac adverse reactions in the elderly and patients with cardiovascular disease; start at lower doses
- Not for myxedema coma; use intravenous thyroid hormone products
- Acute adrenal crisis in adrenal insufficiency; give glucocorticoids first
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (53)
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
- Cholestyramine + Liothyronine Moderate
- Clomipramine + Liothyronine Moderate
- Colesevelam + Liothyronine Moderate
- Dapagliflozin-metformin + Liothyronine Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
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Autres médicaments de cette classe
Questions fréquentes
What is Liothyronine used for?
Liothyronine is a medicine in the class endocrine. It is used for Hypothyroidism, Thyroid cancer.
What side effects have been reported with Liothyronine?
Arrhythmias, Headache, Nervousness, Insomnia, Tremors, Weight loss. Serious warning: Not for treatment of obesity or for weight loss.
Can Liothyronine be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Post-marketing data have not shown more birth defects or miscarriage. Untreated hypothyroidism harms mother and fetus, so do not stop treatment: check TSH and adjust the dose during pregnancy. Levothyroxine is the usual first choice in pregnancy. Breastfeeding: Safe. Liothyronine (T3) is a normal component of milk; replacement doses are not a reason to stop breastfeeding (LactMed). US label: weigh benefits (insufficient data on infant effects). Levothyroxine is recommended for hypothyroidism while breastfeeding.
What does Liothyronine interact with?
MediHelp lists 53 known interactions for Liothyronine. Moderate: 41 · Minor: 12. The most serious include Alogliptin-metformin, Amitriptyline, Amobarbital.
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