Référentiel des médicaments
Chloroprocaine
Chloroprocaine is a medicine in the class central nervous system. It is used for local anesthetic.
- Classe médicamenteuse: Central Nervous System
- Indications: local anesthetic
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Central Nervous System
- Formes courantes
- injection, gel
- Dosages courants
- 24 mg
- Interactions connues
- 4 (Modérée: 2 · Mineure: 2)
- Noms commerciaux
- 2
- Pays et marchés
- 1
Indications
Mécanisme d'action
Like other local anesthetics, chloroprocaine blocks generation and conduction of nerve impulses, presumably by raising the threshold for electrical excitation, slowing impulse propagation and reducing the rate of rise of the action potential.
Posologie adulte habituelle (résumé de la notice)
Local anesthesia (infiltration, peripheral nerve block): maximum single dose without epinephrine 11 mg/kg, not to exceed 800 mg total; with epinephrine (1:200,000) 14 mg/kg, not to exceed 1000 mg total
Grossesse et allaitement
- Grossesse
- Safe Widely used for epidural and spinal anaesthesia in labour and caesarean section. It is broken down in seconds by blood esterases, so very little reaches the fetus. Acceptable when needed.
- Allaitement
- Safe No milk data, but it is cleared from the blood in seconds and other local anaesthetics pass into milk in very low amounts, so infant effects are unlikely. LactMed: lidocaine or ropivacaine may be preferred for a newborn or preterm infant.
Effets indésirables signalés
- Restlessness
- Anxiety
- Dizziness
- Tinnitus
- Blurred vision
- Tremors
Contre-indications
- Hypersensitivity to drugs of the PABA ester group
Précautions particulières
- Use only by clinicians able to manage dose-related toxicity and emergencies, with oxygen and resuscitative equipment immediately available
- Nesacaine multidose vials contain methylparaben and must not be used for lumbar or caudal epidural anesthesia
- Chondrolysis reported after intra-articular infusions of local anesthetics; unapproved use
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (4)
- Chloroprocaine + Dapsone Moderate
- Chloroprocaine + Timolol Moderate
- Chloroprocaine + Nadolol Minor
- Chloroprocaine + Propranolol Minor
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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Questions fréquentes
What is Chloroprocaine used for?
Chloroprocaine is a medicine in the class central nervous system. It is used for Local anesthetic.
What side effects have been reported with Chloroprocaine?
Restlessness, Anxiety, Dizziness, Tinnitus, Blurred vision, Tremors.
Can Chloroprocaine be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Widely used for epidural and spinal anaesthesia in labour and caesarean section. It is broken down in seconds by blood esterases, so very little reaches the fetus. Acceptable when needed. Breastfeeding: Safe. No milk data, but it is cleared from the blood in seconds and other local anaesthetics pass into milk in very low amounts, so infant effects are unlikely. LactMed: lidocaine or ropivacaine may be preferred for a newborn or preterm infant.
What does Chloroprocaine interact with?
MediHelp lists 4 known interactions for Chloroprocaine. Moderate: 2 · Minor: 2. The most serious include Dapsone, Timolol, Nadolol.
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