Interactions médicamenteuses
Chloroprocaine + Dapsone
Gravité: Modérée
Chloroprocaine and Dapsone: moderate interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Both local anesthetics and dapsone can oxidize hemoglobin to methemoglobin. Used together, they may increase the risk of clinically significant methemoglobinemia, causing cyanosis, dyspnea, and tissue hypoxia. Risk is higher in patients with G6PD deficiency or existing anemia.
Ce que signifie cette interaction, en termes simples
Chloroprocaine and Dapsone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroprocaine belongs to Central Nervous System; Dapsone belongs to Anti Bacterial.
Pourquoi elle survient
Additive oxidant stress on hemoglobin from the two drugs leads to formation of methemoglobin.
Conduite à tenir
Use the lowest effective dose of chloroprocaine and watch for cyanosis, low pulse oximetry readings, and dyspnea. Confirm with co-oximetry and treat with methylene blue if symptomatic, unless G6PD deficiency is present.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Chloroprocaine et Dapsone, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 7 jours sur le web. Sans carte.
Autres interactions de Chloroprocaine
- Chloroprocaine + Timolol Modérée
- Chloroprocaine + Nadolol Mineure
- Chloroprocaine + Propranolol Mineure
Autres interactions de Dapsone
- Bcg vaccine live + Dapsone Majeure
- Dapsone + Primaquine Majeure
- Apalutamide + Dapsone Modérée
- Belzutifan + Dapsone Modérée
- Bosentan + Dapsone Modérée
- Bupivacaine implant + Dapsone Modérée
Questions fréquentes
Can I take Chloroprocaine with Dapsone?
MediHelp rates the interaction as moderate. Chloroprocaine and Dapsone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both local anesthetics and dapsone can oxidize hemoglobin to methemoglobin. Used together, they may increase the risk of clinically significant methemoglobinemia, causing cyanosis, dyspnea, and tissue hypoxia. Risk is higher in patients with G6PD deficiency or existing anemia.
How serious is the interaction between Chloroprocaine and Dapsone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose of chloroprocaine and watch for cyanosis, low pulse oximetry readings, and dyspnea. Confirm with co-oximetry and treat with methylene blue if symptomatic, unless G6PD deficiency is present.
What other medicines interact with Chloroprocaine?
MediHelp also lists interactions of Chloroprocaine with, for example, Timolol, Nadolol, Propranolol. The full list is on the Chloroprocaine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
