Référentiel des médicaments
Ivacaftor
Ivacaftor is a medicine in the class miscellaneous. It is used for cystic fibrosis.
- Classe médicamenteuse: Miscellaneous
- Indications: cystic fibrosis
Dernière mise à jour Sources: US FDA label
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
L'essentiel
- Classe médicamenteuse
- Miscellaneous
- Code ATC
- R07AX02
- Formes courantes
- comprimé
- Dosages courants
- 150 mg
- Interactions connues
- 119 (Contre-indiquée: 1 · Majeure: 10 · Modérée: 51 · Mineure: 57)
- Noms commerciaux
- 3
- Pays et marchés
- 3
Indications
Mécanisme d'action
Ivacaftor is a CFTR potentiator that increases chloride transport by increasing the channel open probability (gating) of CFTR protein at the cell surface.
Posologie adulte habituelle (résumé de la notice)
Cystic fibrosis (adults and patients aged 6 years and older): 150 mg orally every 12 hours (300 mg total daily dose) with fat-containing food
Grossesse et allaitement
- Grossesse
- Unknown Limited human data (under 300 pregnancies); no harm in rats or rabbits at 5 to 11 times human exposure. EU label: as a precaution, preferable to avoid. Stopping may worsen cystic fibrosis, and CF teams often continue it, so decide with the CF specialist.
- Allaitement
- Safe Low milk levels and very low infant blood levels; no infant harm reported, and expert groups consider it probably safe. EU label: weigh benefits. LactMed: check the infant's liver tests and eyes (cataracts) periodically, and test for CF, as it can mask it.
Effets indésirables signalés
- Headache
- Upper respiratory tract infection
- Nasal congestion
- Nausea
- Rash
- Oropharyngeal pain
Précautions particulières
- Elevated transaminases: assess ALT/AST before starting, every 3 months in first year, then annually; interrupt dosing if ALT or AST greater than 5 times ULN.
- Hypersensitivity reactions including anaphylaxis reported postmarketing; discontinue and treat if serious signs develop.
- Intracranial hypertension reported with similar active ingredients; interrupt and refer if unusual headache or visual disturbances occur.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (119)
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
- Ivacaftor + Oxcarbazepine Major
- Ivacaftor + Phenobarbitone Major
- Ivacaftor + Phenytoin Major
- Ivacaftor + Rifabutin Major
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour ouvrir la monographie complète de Ivacaftor : posologie, grossesse et allaitement, effets indésirables, mises en garde et toutes les interactions.
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.
Questions fréquentes
What is Ivacaftor used for?
Ivacaftor is a medicine in the class miscellaneous. It is used for Cystic fibrosis.
What side effects have been reported with Ivacaftor?
Headache, Upper respiratory tract infection, Nasal congestion, Nausea, Rash, Oropharyngeal pain.
Can Ivacaftor be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited human data (under 300 pregnancies); no harm in rats or rabbits at 5 to 11 times human exposure. EU label: as a precaution, preferable to avoid. Stopping may worsen cystic fibrosis, and CF teams often continue it, so decide with the CF specialist. Breastfeeding: Safe. Low milk levels and very low infant blood levels; no infant harm reported, and expert groups consider it probably safe. EU label: weigh benefits. LactMed: check the infant's liver tests and eyes (cataracts) periodically, and test for CF, as it can mask it.
What does Ivacaftor interact with?
MediHelp lists 119 known interactions for Ivacaftor. Contraindicated: 1 · Major: 10 · Moderate: 51 · Minor: 57. The most serious include Ensitrelvir, Apalutamide, Carbamazepine.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
