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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Efavirenz + Ivacaftor

Gravité: Majeure

Efavirenz and Ivacaftor: major interaction.

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Résumé

Efavirenz can lower ivacaftor concentrations enough to reduce CFTR potentiation and clinical efficacy. Ivacaftor is a weak CYP3A inhibitor and may modestly raise efavirenz exposure, but the induction effect on ivacaftor is the main concern.

Ce que signifie cette interaction, en termes simples

Efavirenz and Ivacaftor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Efavirenz belongs to Anti Virals; Ivacaftor belongs to Miscellaneous.

Niveau de preuve: Moderate

Pourquoi elle survient

Efavirenz induces CYP3A4, accelerating ivacaftor metabolism; ivacaftor weakly inhibits CYP3A.

Conduite à tenir

Avoid combining ivacaftor with strong CYP3A inducers where possible and consider an alternative antiretroviral. Monitor respiratory status and CF response if used together.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Efavirenz with Ivacaftor?

MediHelp rates the interaction as major. Efavirenz and Ivacaftor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Efavirenz can lower ivacaftor concentrations enough to reduce CFTR potentiation and clinical efficacy. Ivacaftor is a weak CYP3A inhibitor and may modestly raise efavirenz exposure, but the induction effect on ivacaftor is the main concern.

How serious is the interaction between Efavirenz and Ivacaftor?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining ivacaftor with strong CYP3A inducers where possible and consider an alternative antiretroviral. Monitor respiratory status and CF response if used together.

What other medicines interact with Efavirenz?

MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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