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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Ensitrelvir + Ivacaftor

Gravité: Contre-indiquée

Ensitrelvir and Ivacaftor: contraindicated interaction.

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Résumé

The inducing component of lumacaftor/ivacaftor is a strong CYP3A inducer, so combination products lower ensitrelvir levels. Ivacaftor alone is a weak CYP3A substrate with little inducing effect, so the concern applies mainly to lumacaftor-containing regimens. Reduced ensitrelvir exposure may compromise antiviral response.

Ce que signifie cette interaction, en termes simples

Ensitrelvir and Ivacaftor are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Ensitrelvir belongs to Anti Virals; Ivacaftor belongs to Miscellaneous.

Niveau de preuve: Low

Pourquoi elle survient

Lumacaftor (co-formulated with ivacaftor) induces CYP3A, increasing ensitrelvir clearance.

Conduite à tenir

Avoid ensitrelvir in patients taking lumacaftor/ivacaftor and choose an alternative antiviral. Ivacaftor monotherapy does not carry this induction concern but check the exact product.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Ensitrelvir with Ivacaftor?

MediHelp rates the interaction as contraindicated. Ensitrelvir and Ivacaftor are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The inducing component of lumacaftor/ivacaftor is a strong CYP3A inducer, so combination products lower ensitrelvir levels. Ivacaftor alone is a weak CYP3A substrate with little inducing effect, so the concern applies mainly to lumacaftor-containing regimens. Reduced ensitrelvir exposure may compromise antiviral response.

How serious is the interaction between Ensitrelvir and Ivacaftor?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ensitrelvir in patients taking lumacaftor/ivacaftor and choose an alternative antiviral. Ivacaftor monotherapy does not carry this induction concern but check the exact product.

What other medicines interact with Ensitrelvir?

MediHelp also lists interactions of Ensitrelvir with, for example, Apalutamide, Carbamazepine, Colchicine. The full list is on the Ensitrelvir page.

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