Interactions médicamenteuses
Ivacaftor + Oxcarbazepine
Gravité: Majeure
Ivacaftor and Oxcarbazepine: major interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Oxcarbazepine may reduce ivacaftor exposure via CYP3A4 induction. Strong inducers lower ivacaftor exposure substantially, and oxcarbazepine is a weaker inducer with uncertain but possible effects. Loss of CFTR modulator efficacy is possible.
Ce que signifie cette interaction, en termes simples
Ivacaftor and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ivacaftor belongs to Miscellaneous; Oxcarbazepine belongs to Central Nervous System.
Pourquoi elle survient
Oxcarbazepine induces CYP3A4, increasing ivacaftor metabolism.
Conduite à tenir
Prefer a non-inducing anticonvulsant. If it is used, monitor lung function and clinical response to ivacaftor.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Ivacaftor et Oxcarbazepine, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.
Autres interactions de Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contre-indiquée
- Oxcarbazepine + Rilpivirine Contre-indiquée
- Artemether / lumefantrine + Oxcarbazepine Majeure
- Atazanavir + Oxcarbazepine Majeure
- Benzhydrocodone / acetaminophen + Oxcarbazepine Majeure
- Bictegravir + Oxcarbazepine Majeure
Autres interactions de Ivacaftor
- Ensitrelvir + Ivacaftor Contre-indiquée
- Apalutamide + Ivacaftor Majeure
- Carbamazepine + Ivacaftor Majeure
- Clarithromycin + Ivacaftor Majeure
- Efavirenz + Ivacaftor Majeure
- Enzalutamide + Ivacaftor Majeure
Questions fréquentes
Can I take Ivacaftor with Oxcarbazepine?
MediHelp rates the interaction as major. Ivacaftor and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxcarbazepine may reduce ivacaftor exposure via CYP3A4 induction. Strong inducers lower ivacaftor exposure substantially, and oxcarbazepine is a weaker inducer with uncertain but possible effects. Loss of CFTR modulator efficacy is possible.
How serious is the interaction between Ivacaftor and Oxcarbazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing anticonvulsant. If it is used, monitor lung function and clinical response to ivacaftor.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
